Projects
CORECT
The goal of this project is to develop personalized methods for risk-stratifying populations with competing risks. Standard risk models are suboptimal, often mismatching therapy intensity. We created a novel method, generalized competing event (GCE) regression, which uses the omega ratio to stratify patients by their relative risk for competing events. This theory is being tested in the Phase II/III NRG HN004 trial.
HEATMAP
This research focuses on the impact of bone marrow radiation variations on the immune system. We developed image-guided bone marrow-sparing radiotherapy techniques to improve treatment tolerance by limiting radiation to active bone marrow. This approach reduces toxicity and enhances therapy delivery, now being tested in the International Phase III NRG GY006 trial.